Local immunomodulation for cancer therapy
نویسندگان
چکیده
In murine models of cancer, we have achieved efficient systemic activation of tumor-specific T cells by the local administration of a CTLA4-blocking antibody at low doses. Using a slow-release formulation, we could drastically lower the serum levels of the antibody, hence decreasing adverse effects and the risk of autoimmune reactions, without losing systemic efficacy.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013